科研成果 – 张文科教授课题组

PUBLICATIONS

2026

CCS Chemistry01

Force Spectroscopy-Assisted Design of DNAzyme-Loaded Virus-Like Particle System for Synergistic Combination Therapy of Breast Cancer

Fengyun Xu; Nan Li; Wei Zhang; Wenke Zhang

2026 · 1–18 · 在线发表

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Journal of the American Chemical Society02

Interfacial Gold-Gold Interactions Govern the Mechanical Stability of N-Heterocyclic Carbene Self-Assembled Monolayers

Qiuping Mei; Ziwen Ma; Wenke Zhang

2026 · 148(17) · 17581–17586

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Materials Today Bio03

Bioinspired membrane-fusogenic nanomicelles for synergistic chemotherapy, photodynamic therapy, and gas therapy of breast cancer

Nan Li; Fengyun Xu; Wei Zhang; Wenke Zhang

2026 · 36 · 102681

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Polymer04

Chain mobility in crystalline–amorphous polymer networks probed by single-molecule force spectroscopy: Deciphering the impact of the glass transition

Honglin Zhang; Xiaoye Zhang; Ye Chang; Shengjie Lu; Yu Song; Wenke Zhang

2026 · 362 · 130489

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Giant05

A combined AFM and Fourier Transform analysis approach for quantifying surface microstructure evolution in PAN-based carbon fiber processing

Shengjie Lu; Ziwen Ma; Jingfu Dai; Jianzhuo Li; Mingjin Wu; Yuting Jia; Xiaodong Zhang; Li Sun; Jingyi Qian; Wenyu Li; Yudie Chen; Yu Song; Wenke Zhang

2026 · 28 · 100402

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Advanced Materials06

Reversibly Cross-Linked Damage-Tolerant Polymers Breaking the Strength–Stretchability Trade-Off

Jian Li; You‐Liang Zhu; Xiaohan Wang; Shilong Wu; Xingyuan Lu; Quan Chen; Xin Liu; Ziwen Ma; Wenke Zhang; Wenjie Zuo; Zhongyuan Lu; Shuaizheng Bing; Junqi Sun

2026 · e74424 · 在线发表

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Chemical Science07

Ultrahigh-molecular-weight tadpole polymers with statistically symmetric head-to-tail geometry: the key topological intermediate bridging linear and cyclic architectures

Wendi Liang; Jun Gong; Yongkang Deng; Wenjie He; Yiren Wang; Mo Zhu; Xin Guan; Zhi-Chao Yan; Zhi Chen; Xiaopeng Li; Yu Song; Lianwei Li; Wenke Zhang

2026 · 在线发表

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Polymer08

Quantitative characterization of chain folding in crystalline polymers

Yu Song; Yongkang Deng; Wenke Zhang

2026 · 364 · 130638

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2025

Polymer09

A crown-ether-based polyurethane with enhanced energy dissipation via sacrificing host-guest complex structures

Xin Liu; Shengjie Lu; Wenke Zhang

2025 · 333 · 128681

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Langmuir10

Polyethylene Glycolated Shikonin-Functionalized Carbon Nanotubes as an Effective Anticancer System Combining Chemotherapy and Photothermal Therapy

Zhiyuan Liu; Yaxuan Huang; Rui Sun; Nan Li; Fengyun Xu; Wei Zhang; Wenke Zhang

2025 · 41(9) · 6236–6246

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Macromolecules11

Quantitative Correlation of Single-Molecule Mechanical Behavior with the Yield Stress of Polymer Fibers

Xiaoye Zhang; Shengjie Lu; Honglin Zhang; Yu Song; Wenke Zhang

2025 · 58(19) · 10868–10876

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Macromolecules12

Direct Detection of the Chain Trajectory and Long-Range Correlation in Crystalline-Amorphous Polymer Networks by Single-Molecule Force Spectroscopy

Xiaoye Zhang; Honglin Zhang; Shengjie Lu; Yu Song; Wenke Zhang

2025 · 58(12) · 6170–6177

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Colloids and Surfaces A: Physicochemical and Engineering Aspects13

The preparation of shikonin-based nanomedicine with robust GSH-responsiveness

Zhiyuan Liu; Rui Sun; Yaxuan Huang; Fengyun Xu; Nan Li; Wei Zhang; Pengfei Ge; Wenke Zhang

2025 · 705 · 135557

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Advanced Materials14

Ultra-Tough Poly(Urea-Urethane) Plastics With Superior Impact Resistance for Cryogenic Applications

Wenjie Wang; Yixuan Li; Ziwen Ma; Quan Chen; Wenke Zhang; Tiantian Yang; Yihan Xie; Junqi Sun

2025 · 37(39) · 2509421

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2024

Macromolecules15

Single-Molecule Study Reveals Ion-Dependent Conformational Change and Nanomechanical Property of Crown Ether-Based Polymer

Xin Liu; Ruixiang Yao; Zhe Sun; Houyu Zhang; Feng Yan; Hongbin Li; Wenke Zhang

2024 · 57(8) · 3798–3806

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Nanoscale16

Molecular-level periodic arrays of long-chain poly(3-hexylthiophene-2,5-diyl) driven by an electric field

Mingze Ma; Jingyi Qian; Ke Jiang; Liyan Wang; Yu Song; Wenke Zhang

2024 · 16(34) · 15995–16002

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ACS Materials Letters17

Tetrahedral DNA Enhanced Antibacterial Effect of Lysozyme

Yingqi Zhang; Wei Feng; Wenke Zhang

2024 · 6(6) · 2409–2415

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Review of Scientific Instruments18

An atomic force microscopy and total internal reflection fluorescence microscopy correlated system (AFM–TIRF) for fluorescence imaging and spectroscopy of a single particle

Xiumian Cao; Wenquan Wang; Yuanfei Jiang; Wei Feng; Shuping Xu; Weiqing Xu; Wenke Zhang

2024 · 95(7) · 073706

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2023

Acta Biomaterialia19

Exploring the impact of PEGylation on the cell-nanomicelle interactions by AFM-based single-molecule force spectroscopy and force tracing

Jue Hou; Nan Li; Wei Zhang; Wenke Zhang

2023 · 157 · 310–320

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ACS Macro Letters20

Increasing the Mechanical Stability of Polymer-Gold Interfacial Connection: A Parallel Covalent Strategy

Ziwen Ma; Honglin Zhang; Yu Song; Qiuping Mei; Pengju Shi; Joon Won Park; Wenke Zhang

2023 · 12(4) · 421–427

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Macromolecules21

Dynamic Distribution of αc-Relaxation in Polyethylene Single Crystals Investigated by Single-Molecule Force Spectroscopy

Xiaoye Zhang; Peng Yang; Shengjie Lu; Yongkang Deng; Ziwen Ma; Yu Song; Wenke Zhang

2023 · 56(12) · 4621–4628

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中国科学化学22

聚合物力化学的单分子力谱研究

Shengjie Lu; Yu Song; Wenke Zhang

2023 · 53(4) · 708–720

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2022

Macromolecular Rapid Communications23

Chemical Fuel Mediated Self-Regulatory Polymer Brushes for Autonomous Fluorescence Modulator and Wettability Switcher

Mengyuan Li; Ziwen Ma; Chunyu Pan; Xiaoye Zhang; Wenke Zhang; Bai Yang; Yunfeng Li

2022 · 43(7) · 2100878

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Macromolecules24

Manipulation of a Single Polymer Chain: From the Nanomechanical Properties to Dynamic Structure Evolution

Yu Song; Ziwen Ma; Wenke Zhang

2022 · 55(11) · 4177–4199

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CCS Chemistry25

Identification of the New Type of G-Quadruplex with Multiple Vacant Sites in Human Telomeric DNA

Xiaonong Zhang; Xiaolong Kou; Wei Zhang; Wenke Zhang

2022 · 4(9) · 3023–3035

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Polymer26

Single-molecule study on the force-induced melting in syndiotactic polypropylene single crystals

Xiaoye Zhang; Dandan Li; Yu Song; Wenke Zhang

2022 · 256 · 125187

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Macromolecules27

Coil–Globule Transition of a Water-Soluble Polymer

Jianyu Liu; Huazhang Guo; Qingjie Gao; Hongbin Li; Zesheng An; Wenke Zhang

2022 · 55(19) · 8524–8532

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Chinese Journal of Polymer Science28

Exploring the Nanomechanical Properties of a Coordination-bond Based Supramolecular Polymer

Rui-Xiang Yao; Jun-Juan Shi; Ke-Huan Li; Xin Liu; Hou-Yu Zhang; Ming Wang; Wen-Ke Zhang

2022 · 40(12) · 1613–1622

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2021

Nano Research29

Single-molecule observation of mechanical isomerization of spirothiopyran and subsequent Click addition

Ruixiang Yao; Xun Li; Nan Xiao; Wengui Weng; Wenke Zhang

2021 · 14(8) · 2654–2658

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高分子学报30

基于原子力显微镜的单分子力谱技术在高分子表征中的应用

张薇; 侯矍; 李楠; 张文科

2021 · 52(11) · 1523–1546

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2020

Macromolecules31

Side-Chain Length Dependence of Young's Modulus and Strength in Crystalline Poly(3-alkylthiophene) Nanofibers

Ke Jiang; Liang Wang; Xiaoye Zhang; Ziwen Ma; Yu Song; Wenke Zhang

2020 · 53(22) · 10061–10068

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ACS Macro Letters32

Quantifying the Mechanical Anisotropy in Poly(3-hexylthiophene) Nanofibers

Ke Jiang; Daren Xu; Ziwen Ma; Peng Yang; Yu Song; Wenke Zhang

2020 · 9(1) · 108–114

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Nanoscale33

A single-molecule study reveals novel rod-like structures formed by a thrombin aptamer repeat sequence

Jianyu Liu; Wei Feng; Wenke Zhang

2020 · 12(6) · 4159–4166

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Nucleic Acids Research34

Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro

Xiaonong Zhang; Yingqi Zhang; Wenke Zhang

2020 · 48(12) · 6458–6470

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Macromolecular Rapid Communications35

Effects of Psoralen on Histone-DNA Interactions Studied by Using Atomic Force Microscopy

Yingqi Zhang; Xiaonong Zhang; Wei Zhang; Wenke Zhang

2020 · 41(24) · 2000017

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Macromolecular Rapid Communications36

Nanomechanical Properties of a Supramolecular Helix Stabilized by Non-Covalent Interactions

Huijie Wang; Bowen Shen; Yu Song; Myongsoo Lee; Wenke Zhang

2020 · 41(24) · 2000453

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2019

Nanoscale37

A single-molecule atomic force microscopy study reveals the antiviral mechanism of tannin and its derivatives

Huijie Wang; Ying Chen; Wenke Zhang

2019 · 11(35) · 16368–16376

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Macromolecules38

Single-Molecule Force Spectroscopy Study on Force-Induced Melting in Polymer Single Crystals: The Chain Conformation Matters

Yu Song; Ziwen Ma; Peng Yang; Xiaoye Zhang; Xiujuan Lyu; Ke Jiang; Wenke Zhang

2019 · 52(3) · 1327–1333

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ACS Macro Letters39

Quantifying the Chain Folding in Polymer Single Crystals by Single-Molecule Force Spectroscopy

Ziwen Ma; Peng Yang; Xiaoye Zhang; Ke Jiang; Yu Song; Wenke Zhang

2019 · 8(9) · 1194–1199

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Chemistry – An Asian Journal40

Quantifying the Bonding Strength of Gold-Chalcogen Bonds in Block Copolymer Systems

Wentian Xiang; Zhandong Li; Cong‐Qiao Xu; Jun Li; Wenke Zhang; Huaping Xu

2019 · 14(9) · 1481–1486

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2018

Chemical Journal of Chinese Universities41

Nanomechanics of Polyphenylacetylene Derivatives by AFM-based SMFS

Xun Li; Xiao Wang; Ruixiang Yao; Jingzhi Sun; Wenke Zhang

2018 · 39(11) · 2565–2571

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Nanoscale42

Direct observation of the wrapping/unwrapping of ssDNA around/from a SWCNT at the single-molecule level: towards tuning the binding mode and strength

Zhandong Li; Yu Song; Aisen Li; Weiqing Xu; Wenke Zhang

2018 · 10(39) · 18586–18596

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Langmuir43

Atomic Force Microscopy Imaging Study of Aligning DNA by Dumbbell-like Au-Fe3O4 Magnetic Nanoparticles

Jianyu Liu; Xinxin Wang; Wenke Zhang

2018 · 34(49) · 14875–14881

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Chemical Journal of Chinese Universities44

Single Molecule Force Spectroscopy Study on the Apparent Nanomechanical Properties of Polyethylene Single Crystals

Xiujuan Lü; Yu Song; Wenke Zhang

2018 · 39(1) · 166–171

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Macromolecules45

Unfolding of a Single Polymer Chain from the Single Crystal by Air-Phase Single-Molecule Force Spectroscopy: Toward Better Force Precision and More Accurate Description of Molecular Behaviors

Peng Yang; Yu Song; Wei Feng; Wenke Zhang

2018 · 51(18) · 7052–7060

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ACS Macro Letters46

Direct Observation of Single-Molecule Stick–Slip Motion in Polyamide Single Crystals

Xiujuan Lyu; Yu Song; Wei Feng; Wenke Zhang

2018 · 7(6) · 762–766

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高分子学报47

聚氧乙烯单晶介观力学性质研究

吕秀娟; 宋宇; 张文科

2018 · (6) · 748–754

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Japanese Journal of Applied Physics48

Single molecule study on the mechanical response of the sixth domain of adseverin

Yang Xiao; Yi Cao; Wenke Zhang

2018 · 57(8S1) · 08NB06

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高等学校化学学报49

硫醚-金配位相互作用的单分子力谱研究

李逊; 薛玉瑞; 宋宇; 张文科

2018 · 39(12) · 2774–2780

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2017

Langmuir50

Single Molecule Study on Polymer-Nanoparticle Interactions: The Particle Shape Matters

Zhandong Li; Bin Zhang; Yu Song; Yurui Xue; Lixin Wu; Wenke Zhang

2017 · 33(31) · 7615–7621

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Langmuir51

Effect of Chain Conformation on the Single-Molecule Melting Force in Polymer Single Crystals: Steered Molecular Dynamics Simulations Study

Wei Feng; Zhigang Wang; Wenke Zhang

2017 · 33(8) · 1826–1833

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Nature Communications52

Multi-modal mechanophores based on cinnamate dimers

Huan Zhang; Xun Li; Yangju Lin; Fei Gao; Zhen Tang; Peifeng Su; Wenke Zhang; Yuanze Xu; Wengui Weng; Roman Boulatov

2017 · 8(1) · 1147

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2016

ACS Applied Materials & Interfaces53

Quantifying the Interactions between PEI and Double-Stranded DNA: Toward the Understanding of the Role of PEI in Gene Delivery

Xiaolong Kou; Wei Zhang; Wenke Zhang

2016 · 8(32) · 21055–21062

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2015

Nanoscale54

Investigation of the binding modes between AIE-active molecules and dsDNA by single molecule force spectroscopy

Ying Chen; Ke Ma; Ting Hu; Bo Jiang; Bin Xu; Wenjing Tian; Jing Zhi Sun; Wenke Zhang

2015 · 7(19) · 8939–8945

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2014

Chinese Journal of Polymer Science55

Investigation on the folding mode of a polymer chain in a spiral crystal by single molecule force spectroscopy

Yu Song; Wei Feng; Wen-ke Zhang

2014 · 32(9) · 1149–1157

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Nature Communications56

Quantifying thiol–gold interactions towards the efficient strength control

Yurui Xue; Xun Li; Hongbin Li; Wenke Zhang

2014 · 5(1) · 4348

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化学学报57

硫酸钠诱导单链聚(N-异丙基丙烯酰胺)相变的单分子力谱研究

Yurui Xue; Wenke Zhang

2014 · 72(4) · 481–486

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2013

Acta Chimica Sinica58

Evaluation on the Stability of the Intramolecular N-H ••• OMe Hydrogen Bonds of Aromatic Amide Foldamers

Zhuming Shi; Yu Song; Fang Lu; Tianyou Zhou; Xin Zhao; Wenke Zhang; Zhanting Li

2013 · 71(1) · 51–61

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Langmuir59

Exploring the Folding Pattern of a Polymer Chain in a Single Crystal by Combining Single-Molecule Force Spectroscopy and Steered Molecular Dynamics Simulations

Yu Song; Wei Feng; Kai Liu; Peng Yang; Wenke Zhang; Xi Zhang

2013 · 29(12) · 3853–3857

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Biophysical Journal60

Single-Molecule Force Spectroscopy Study on the Mechanism of RNA Disassembly in Tobacco Mosaic Virus

Ningning Liu; Ying Chen; Bo Peng; Yuan Lin; Qian Wang; Zhaohui Su; Wenke Zhang; Hongbin Li; Jiacong Shen

2013 · 105(12) · 2790–2800

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2012

ChemPhysChem61

Feeling Inter- or Intramolecular Interactions with the Polymer Chain as Probe: Recent Progress in SMFS Studies on Macromolecular Interactions

Ningning Liu; Wenke Zhang

2012 · 13(9) · 2238–2256

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高等学校化学学报62

聚合物单分子力谱的研究进展

张薇; 寇晓龙; 张文科

2012 · 33(5) · 861–875

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2011

Journal of the American Chemical Society63

Extracting a Single Polyethylene Oxide Chain from a Single Crystal by a Combination of Atomic Force Microscopy Imaging and Single-Molecule Force Spectroscopy: Toward the Investigation of Molecular Interactions in Their Condensed States

Kai Liu; Yu Song; Wei Feng; Ningning Liu; Wenke Zhang; Xi Zhang

2011 · 133(10) · 3226–3229

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Acta Polymerica Sinica64

AFM Imaging and Single-Molecule Force Spectroscopy Studies on Macromolecular Interactions at Single-Molecule Level

Wenke Zhang

2011 · (9) · 913–922

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Langmuir65

EMSA and Single-Molecule Force Spectroscopy Study of Interactions between Bacillus subtilis Single-Stranded DNA-Binding Protein and Single-Stranded DNA

Wei Zhang; Xiujuan Lü; Wenke Zhang; Jiacong Shen

2011 · 27(24) · 15008–15015

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Science China Chemistry66

Self-assembly of anisotropic tobacco mosaic virus nanoparticles on gold substrate

Bo Peng; NingNing Liu; Yuan Lin; LiMing Wang; WenKe Zhang; ZhongWei Niu; Qian Wang; ZhaoHui Su

2011 · 54(1) · 137–143

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2010

Langmuir67

The Nature of the Force-Induced Conformation Transition of dsDNA Studied by Using Single Molecule Force Spectroscopy

Ningning Liu; Tianjia Bu; Yu Song; Wei Zhang; Jinjing Li; Wenke Zhang; Jiacong Shen; Hongbin Li

2010 · 26(12) · 9491–9496

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Journal of the American Chemical Society68

Pulling Genetic RNA out of Tobacco Mosaic Virus Using Single-Molecule Force Spectroscopy

Ningning Liu; Bo Peng; Yuan Lin; Zhaohui Su; Zhongwei Niu; Qian Wang; Wenke Zhang; Hongbin Li; Jiacong Shen

2010 · 132(32) · 11036–11038

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