State Key Laboratory of Supramolecular Structure and Materials, Jilin University Wenke Zhang Research Group
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Single-Molecule Science and Functional Materials

Understanding Molecular Forces.Connecting Materials and Life.

We develop methods to study individual molecules and particles, exploring polymer mechanics in condensed states, mechanochemistry, and biological interfaces. By connecting microscopic structure with material function, we guide the design of high-performance polymers, supramolecular materials, and nanomedicines.

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Wenke Zhang Research Group at Jilin University
01

Nanomedicine Design and Development

We combine single-particle mechanical measurements with trajectory and life-cycle tracking to evaluate and develop nanomedicine delivery systems and effective supramolecular therapeutics for cancer treatment.

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02

Single-Molecule Mechanochemistry and High-Performance Supramolecular Materials

We use single-molecule force spectroscopy to investigate covalent and supramolecular mechanochemistry, translating molecular force responses into high-performance supramolecular materials that respond to multiple stimuli.

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03

Nanomechanics of Polymers in Condensed States

We study crystalline, semicrystalline, and amorphous polymers using single-molecule force spectroscopy, connecting chain structure and nanomechanics with macroscopic properties to guide the design of high-performance polymer materials.

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04

Developing New Single-Molecule Techniques

We combine the high spatial and temporal resolution of single-molecule force spectroscopy with the chemical specificity of infrared spectroscopy, developing coupled in situ methods to reveal the mechanisms of single-molecule mechanochemistry.

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News

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  1. August 2026Qiuping Mei Receives an Outstanding Poster Award at ISSST2026
  2. August 2026Qiuping Mei Receives a Poster Award at the 15th Jilin-Korea-Waseda Alliance Annual Symposium
  3. June 2026Congratulations to Our Master’s Graduates Ye Chang, Yuchao Guo, and Yaxuan Huang

Featured Publications

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  1. 2026 · J. Am. Chem. Soc.Interfacial Gold-Gold Interactions Govern the Mechanical Stability of N-Heterocyclic Carbene Self-Assembled Monolayers
  2. 2026 · CCS ChemistryForce Spectroscopy-Assisted Design of DNAzyme-Loaded Virus-Like Particle System for Synergistic Combination Therapy of Breast Cancer
  3. 2025 · MacromoleculesQuantitative Correlation of Single-Molecule Mechanical Behavior with the Yield Stress of Polymer Fibers