{"id":232,"date":"2026-09-17T11:11:27","date_gmt":"2026-09-17T03:11:27","guid":{"rendered":"https:\/\/www.zhangwenkegroup.com\/?page_id=232"},"modified":"2026-09-19T14:37:36","modified_gmt":"2026-09-19T06:37:36","slug":"research-directions","status":"publish","type":"page","link":"https:\/\/www.zhangwenkegroup.com\/index.php\/research-directions\/","title":{"rendered":"\u7814\u7a76\u65b9\u5411"},"content":{"rendered":"\n<style>\n\n.zg-research{--zg-ink:#f4f9fc;--zg-copy:#d8e7f0;--zg-line:rgba(188,220,241,.23);--zg-mist:#c9dce6;box-sizing:border-box;width:100%;max-width:1280px;margin:0 auto;color:var(--zg-ink);font-family:inherit;background:transparent;text-align:left;}\n.zg-research *{box-sizing:border-box;}\n.zg-research .zg-overview,.zg-research .zg-section{position:relative;border:1px solid var(--zg-line);border-radius:20px;background:rgba(6,27,44,.86);box-shadow:0 18px 48px rgba(0,8,18,.17);padding:clamp(22px,3.2vw,42px);}\n.zg-research 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class=\"zg-lead\">\u57fa\u4e8e\u539f\u5b50\u529b\u663e\u5fae\u955c\uff08AFM\uff09\u7684\u5355\u5206\u5b50\u4e0e\u5355\u7c92\u5b50\u64cd\u7eb5\u6280\u672f\uff0c\u4e3a\u8ba4\u8bc6\u8d85\u5206\u5b50\u7ed3\u6784\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\u63d0\u4f9b\u4e86\u6709\u529b\u5de5\u5177\u3002\u4f9d\u6258\u8fd9\u4e00\u6280\u672f\uff0c\u6211\u4eec\u56f4\u7ed5\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u3001\u5355\u5206\u5b50\u529b\u5316\u5b66\u4e0e\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599\u3001\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u5f00\u5c55\u7cfb\u7edf\u7814\u7a76\u3002\u9762\u5411\u8fd9\u4e9b\u7814\u7a76\u63d0\u51fa\u7684\u65b0\u9700\u6c42\uff0c\u6211\u4eec\u8fdb\u4e00\u6b65\u62d3\u5c55\u6d4b\u91cf\u73af\u5883\u548c\u4fe1\u606f\u83b7\u53d6\u7ef4\u5ea6\uff0c\u53d1\u5c55\u80fd\u591f\u5173\u8054\u5206\u5b50\u7ed3\u6784\u3001\u529b\u5b66\u54cd\u5e94\u4e0e\u5316\u5b66\u53d8\u5316\u7684\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u3002<\/p><figure class=\"zg-motion\"><div class=\"zg-motion-canvas\"><img fetchpriority=\"high\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u8c31\u603b\u89c8\u52a8\u753b\u5c01\u9762.jpg\" data-animation=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u8c31\u603b\u89c8\u52a8\u753b.webp\" data-still=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u8c31\u603b\u89c8\u52a8\u753b\u5c01\u9762.jpg\" alt=\"\u5355\u5206\u5b50\u529b\u8c31\u603b\u89c8\" width=\"960\" height=\"540\" loading=\"eager\" decoding=\"async\"\/><\/div><button class=\"zg-motion-toggle\" type=\"button\" aria-label=\"\u6682\u505c\u5355\u5206\u5b50\u529b\u8c31\u603b\u89c8\" aria-pressed=\"false\" hidden>\u6682\u505c<\/button><\/figure><div class=\"zg-references\"><h2>\u4ee3\u8868\u8bba\u6587<\/h2><ol><li>Song, Y.; Ma, Z.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1021\/acs.macromol.2c00076\" target=\"_blank\" rel=\"noopener\">Manipulation of a Single Polymer Chain: From the Nanomechanical Properties to Dynamic Structure Evolution<\/a>. <em>Macromolecules<\/em> <strong>2022<\/strong>, <em>55<\/em> (11), 4177\u20134199.<\/li><li>\u5f20\u8587; \u4faf\u77cd; \u674e\u6960; \u5f20\u6587\u79d1. <a href=\"https:\/\/doi.org\/10.11777\/j.issn1000-3304.2020.20266\" target=\"_blank\" rel=\"noopener\">\u57fa\u4e8e\u539f\u5b50\u529b\u663e\u5fae\u955c\u7684\u5355\u5206\u5b50\u529b\u8c31\u6280\u672f\u5728\u9ad8\u5206\u5b50\u8868\u5f81\u4e2d\u7684\u5e94\u7528<\/a>. <em>\u9ad8\u5206\u5b50\u5b66\u62a5<\/em> <strong>2021<\/strong>, <em>52<\/em> (11), 1523\u20131546.<\/li><\/ol><\/div><\/div>\n<section aria-labelledby=\"nanomedicine-title\" class=\"zg-section\" id=\"nanomedicine\" style=\"--zg-accent:#b2c1e1\"><div class=\"zg-heading\"><span aria-hidden=\"true\" class=\"zg-number\">01<\/span><h2 id=\"nanomedicine-title\">\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1<\/h2><\/div>\n<div class=\"zg-topic-grid\"><div class=\"zg-copy\"><p class=\"zg-intro\"><strong>\u7814\u7a76\u95ee\u9898\uff1a<\/strong>\u7eb3\u7c73\u8f7d\u4f53\u5982\u4f55\u4e0e\u7ec6\u80de\u819c\u8bc6\u522b\u3001\u7ed3\u5408\u5e76\u8de8\u819c\u8fd0\u8f93\uff1f\u8868\u9762\u4fee\u9970\u3001\u9776\u5411\u914d\u4f53\u53ca\u975e\u7279\u5f02\u6027\u76f8\u4e92\u4f5c\u7528\u5982\u4f55\u5f71\u54cd\u9012\u9001\u6548\u7387\uff1f\u6211\u4eec\u5173\u6ce8\u7eb3\u7c73\u836f\u7269\u5728\u751f\u7269\u754c\u9762\u7684\u884c\u4e3a\u4e0e\u5176\u6cbb\u7597\u529f\u80fd\u4e4b\u95f4\u7684\u8054\u7cfb\u3002<\/p><p 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class=\"zg-topic-media\"><figure class=\"zg-motion\"><div class=\"zg-motion-canvas\"><img alt=\"\u7eb3\u7c73\u836f\u7269\u4e0e\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u52a8\u6001\u793a\u610f\" data-animation=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u52a8\u753b.webp\" data-still=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u5c01\u9762.jpg\" decoding=\"async\" height=\"720\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u5c01\u9762.jpg\" width=\"960\"\/><\/div><button aria-label=\"\u6682\u505c\u7eb3\u7c73\u836f\u7269\u4e0e\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u52a8\u6001\u793a\u610f\" aria-pressed=\"false\" class=\"zg-motion-toggle\" hidden=\"\" type=\"button\">\u6682\u505c<\/button><\/figure><figure class=\"zg-figure\"><a class=\"zg-figure-link\" href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u56fe\u793a.jpg\" rel=\"noopener noreferrer\" target=\"_blank\"><img alt=\"\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u7814\u7a76\u56fe\u793a\" decoding=\"async\" height=\"639\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u56fe\u793a-scaled.jpg\" width=\"3569\"\/><\/a><figcaption><a href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u4e0e\u5f00\u53d1\u56fe\u793a.jpg\" rel=\"noopener noreferrer\" target=\"_blank\">\u67e5\u770b\u5927\u56fe \u2197<\/a><\/figcaption><\/figure><\/div><\/div>\n<div class=\"zg-references\"><h3>\u4ee3\u8868\u8bba\u6587<\/h3><ol><li>Xu, F.; Li, N.; Zhang, W.; Zhang, W. <a href=\"https:\/\/doi.org\/10.31635\/ccschem.026.202507248\" rel=\"noopener\" target=\"_blank\">Force Spectroscopy-Assisted Design of DNAzyme-Loaded Virus-Like Particle System for Synergistic Combination Therapy of Breast Cancer<\/a>. <em>CCS Chem.<\/em> <strong>2026<\/strong>, 1\u201318 (ASAP).<\/li><li>Li, N.; Xu, F.; Zhang, W.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1016\/j.mtbio.2025.102681\" rel=\"noopener\" target=\"_blank\">Bioinspired membrane-fusogenic nanomicelles for synergistic chemotherapy, photodynamic therapy, and gas therapy of breast cancer<\/a>. <em>Mater. Today Bio<\/em> <strong>2026<\/strong>, <em>36<\/em>, 102681.<\/li><li>Hou, J.; Li, N.; Zhang, W.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1016\/j.actbio.2022.12.020\" rel=\"noopener\" target=\"_blank\">Exploring the impact of PEGylation on the cell-nanomicelle interactions by AFM-based single-molecule force spectroscopy and force tracing<\/a>. <em>Acta Biomater.<\/em> <strong>2023<\/strong>, <em>157<\/em>, 310\u2013320.<\/li><li>Zhang, Y.; Feng, W.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1021\/acsmaterialslett.4c00662\" rel=\"noopener\" target=\"_blank\">Tetrahedral DNA Enhanced Antibacterial Effect of Lysozyme<\/a>. <em>ACS Mater. Lett.<\/em> <strong>2024<\/strong>, <em>6<\/em> (6), 2409\u20132415.<\/li><\/ol><\/div><\/section>\n\n<section aria-labelledby=\"mechanochemistry-title\" class=\"zg-section\" id=\"mechanochemistry\" style=\"--zg-accent:#9bd3cb\"><div class=\"zg-heading\"><span aria-hidden=\"true\" class=\"zg-number\">02<\/span><h2 id=\"mechanochemistry-title\">\u5355\u5206\u5b50\u529b\u5316\u5b66\u4e0e\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599<\/h2><\/div>\n<div class=\"zg-topic-grid\"><div class=\"zg-copy\"><p class=\"zg-intro\"><strong>\u7814\u7a76\u95ee\u9898\uff1a<\/strong>\u673a\u68b0\u529b\u5982\u4f55\u6539\u53d8\u5206\u5b50\u6784\u8c61\u3001\u8c03\u63a7\u76f8\u4e92\u4f5c\u7528\u5e76\u9a71\u52a8\u5316\u5b66\u53cd\u5e94\uff1f\u5206\u5b50\u4e0e\u91d1\u5c5e\u754c\u9762\u7684\u8fde\u63a5\u7ed3\u6784\u3001\u79bb\u5b50\u53ca\u5c40\u57df\u73af\u5883\u5982\u4f55\u5f71\u54cd\u8f7d\u8377\u4f20\u9012\u3001\u5931\u6548\u4e0e\u53ef\u9006\u6027\uff1f\u6211\u4eec\u5e0c\u671b\u5efa\u7acb\u5355\u5206\u5b50\u53d7\u529b\u884c\u4e3a\u4e0e\u5b8f\u89c2\u6750\u6599\u6027\u80fd\u4e4b\u95f4\u7684\u8054\u7cfb\u3002<\/p><p class=\"zg-intro\"><strong>\u5177\u4f53\u5de5\u4f5c\uff1a<\/strong>\u5229\u7528\u5355\u5206\u5b50\u529b\u8c31\u4e0e\u7406\u8bba\u8ba1\u7b97\uff0c\u7814\u7a76\u529b\u54cd\u5e94\u57fa\u56e2\u6d3b\u5316\u3001\u5316\u5b66\u952e\u65ad\u88c2\u53ca\u540e\u7eed\u53cd\u5e94\uff0c\u63a2\u7d22\u63d0\u9ad8\u754c\u9762\u7a33\u5b9a\u6027\u7684\u8fde\u63a5\u7b56\u7565\u3002\u56f4\u7ed5\u4e3b\u5ba2\u4f53\u8bc6\u522b\u3001\u914d\u4f4d\u4f5c\u7528\u4e0e\u6c22\u952e\u89e3\u6790\u53d7\u529b\u6784\u8c61\u548c\u7ed3\u5408\u72b6\u6001\uff1b\u5c06\u51a0\u919a\u7b49\u529f\u80fd\u5355\u5143\u5f15\u5165\u805a\u5408\u7269\uff0c\u8c03\u8282\u80fd\u91cf\u8017\u6563\uff0c\u7ed3\u5408\u5b8f\u89c2\u529b\u5b66\u6d4b\u8bd5\u53d1\u5c55\u517c\u5177\u5f3a\u5ea6\u3001\u97e7\u6027\u548c\u523a\u6fc0\u54cd\u5e94\u80fd\u529b\u7684\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599\u3002<\/p><\/div><div class=\"zg-topic-media\"><figure class=\"zg-motion zg-motion--dark\"><div class=\"zg-motion-canvas\"><img alt=\"\u5355\u5206\u5b50\u529b\u5316\u5b66\u5206\u5b50\u6a21\u578b\u52a8\u6001\u793a\u610f\" data-animation=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u5316\u5b66\u4e0e\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599\u52a8\u753b.webp\" data-still=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u5316\u5b66\u52a8\u753b\u5c01\u9762.jpg\" decoding=\"async\" height=\"540\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u5316\u5b66\u52a8\u753b\u5c01\u9762.jpg\" width=\"960\"\/><\/div><button aria-label=\"\u6682\u505c\u5355\u5206\u5b50\u529b\u5316\u5b66\u5206\u5b50\u6a21\u578b\u52a8\u6001\u793a\u610f\" aria-pressed=\"false\" class=\"zg-motion-toggle\" hidden=\"\" type=\"button\">\u6682\u505c<\/button><\/figure><figure class=\"zg-figure\"><a class=\"zg-figure-link\" href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u5316\u5b66\u4e0e\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599\u56fe\u793a.png\" rel=\"noopener noreferrer\" target=\"_blank\"><img alt=\"\u5355\u5206\u5b50\u529b\u5316\u5b66\u4e0e\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599\u7814\u7a76\u56fe\u793a\" decoding=\"async\" height=\"1303\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u5316\u5b66\u4e0e\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599\u56fe\u793a-scaled.png\" width=\"5137\"\/><\/a><figcaption><a href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u5355\u5206\u5b50\u529b\u5316\u5b66\u4e0e\u9ad8\u6027\u80fd\u8d85\u5206\u5b50\u6750\u6599\u56fe\u793a.png\" rel=\"noopener noreferrer\" target=\"_blank\">\u67e5\u770b\u5927\u56fe \u2197<\/a><\/figcaption><\/figure><\/div><\/div>\n<div class=\"zg-references\"><h3>\u4ee3\u8868\u8bba\u6587<\/h3><ol><li>Mei, Q.; Ma, Z.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1021\/jacs.6c02482\" rel=\"noopener\" target=\"_blank\">Interfacial Gold-Gold Interactions Govern the Mechanical Stability of N-Heterocyclic Carbene Self-Assembled Monolayers<\/a>. <em>J. Am. Chem. Soc.<\/em> <strong>2026<\/strong>, <em>148<\/em> (17), 17581\u201317586.<\/li><li>Liu, X.; Yao, R.; Sun, Z.; Zhang, H.; Yan, F.; Li, H.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1021\/acs.macromol.3c02552\" rel=\"noopener\" target=\"_blank\">Single-Molecule Study Reveals Ion-Dependent Conformational Change and Nanomechanical Property of Crown Ether-Based Polymer<\/a>. <em>Macromolecules<\/em> <strong>2024<\/strong>, <em>57<\/em> (8), 3798\u20133806.<\/li><li>Zhang, H.; Li, X.; Lin, Y.; Gao, F.; Tang, Z.; Su, P.; Zhang, W.; Xu, Y.; Weng, W.; Boulatov, R. <a href=\"https:\/\/doi.org\/10.1038\/s41467-017-01412-8\" rel=\"noopener\" target=\"_blank\">Multi-modal mechanophores based on cinnamate dimers<\/a>. <em>Nat. Commun.<\/em> <strong>2017<\/strong>, <em>8<\/em> (1), 1147.<\/li><li>Xue, Y.; Li, X.; Li, H.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1038\/ncomms5348\" rel=\"noopener\" target=\"_blank\">Quantifying thiol\u2013gold interactions towards the efficient strength control<\/a>. <em>Nat. Commun.<\/em> <strong>2014<\/strong>, <em>5<\/em> (1), 4348.<\/li><\/ol><\/div><\/section>\n\n<section aria-labelledby=\"condensed-polymer-title\" class=\"zg-section\" id=\"condensed-polymer\" style=\"--zg-accent:#9bcfe8\"><div class=\"zg-heading\"><span aria-hidden=\"true\" class=\"zg-number\">03<\/span><h2 id=\"condensed-polymer-title\">\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66<\/h2><\/div>\n<div class=\"zg-topic-grid\"><div class=\"zg-copy\"><p class=\"zg-intro\"><strong>\u7814\u7a76\u95ee\u9898\uff1a<\/strong>\u5206\u5b50\u94fe\u7684\u5316\u5b66\u7ed3\u6784\u3001\u94fe\u6298\u53e0\u3001\u5206\u5b50\u5806\u79ef\u548c\u975e\u6676\u94fe\u8fde\u63a5\u65b9\u5f0f\u5982\u4f55\u5171\u540c\u51b3\u5b9a\u805a\u5408\u7269\u7684\u529b\u5b66\u6027\u80fd\uff1f\u6676\u4f53\u4e0e\u975e\u6676\u7f51\u7edc\u4e2d\u7684\u5355\u94fe\u8fd0\u52a8\u5982\u4f55\u53c2\u4e0e\u5e94\u529b\u4f20\u9012\uff0c\u5e76\u5f71\u54cd\u7ea4\u7ef4\u5c48\u670d\u7b49\u5b8f\u89c2\u53d8\u5f62\u884c\u4e3a\uff1f<\/p><p class=\"zg-intro\"><strong>\u5177\u4f53\u5de5\u4f5c\uff1a<\/strong>\u9762\u5411\u7ed3\u6676\u3001\u534a\u7ed3\u6676\u4e0e\u975e\u6676\u6001\u805a\u5408\u7269\uff0c\u5229\u7528\u539f\u5b50\u529b\u663e\u5fae\u955c\u548c\u5355\u5206\u5b50\u529b\u8c31\u7814\u7a76\u5355\u6676\u3001\u7403\u6676\u53ca\u7ea4\u7ef4\u4e2d\u7684\u94fe\u53d7\u529b\u884c\u4e3a\u3002\u901a\u8fc7\u4ece\u5355\u6676\u4e2d\u63d0\u62c9\u5355\u6839\u5206\u5b50\u94fe\uff0c\u89e3\u6790\u94fe\u6298\u53e0\u3001\u53d7\u529b\u7194\u878d\u3001\u6ed1\u79fb\u4e0e\u677e\u5f1b\uff0c\u8003\u5bdf\u6784\u8c61\u3001\u6676\u4f53\u539a\u5ea6\u3001\u6676\u578b\u53ca\u6e29\u5ea6\u7684\u5f71\u54cd\uff1b\u7814\u7a76\u94fe\u8fc1\u79fb\u3001\u957f\u7a0b\u8fd0\u52a8\u5173\u8054\u548c\u7cfb\u5e26\u94fe\u627f\u529b\uff0c\u7ed3\u5408\u7eb3\u7c73\u529b\u5b66\u4e0e\u5b8f\u89c2\u62c9\u4f38\u6d4b\u8bd5\u5efa\u7acb\u5355\u94fe\u7ed3\u6784\u4e0e\u6750\u6599\u6027\u80fd\u7684\u8054\u7cfb\u3002<\/p><\/div><div class=\"zg-topic-media\"><figure class=\"zg-motion\"><div class=\"zg-motion-canvas\"><img alt=\"\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u52a8\u6001\u793a\u610f\" data-animation=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u52a8\u753b.webp\" data-still=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u52a8\u753b\u5c01\u9762.jpg\" decoding=\"async\" height=\"640\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u52a8\u753b\u5c01\u9762.jpg\" width=\"960\"\/><\/div><button aria-label=\"\u6682\u505c\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u52a8\u6001\u793a\u610f\" aria-pressed=\"false\" class=\"zg-motion-toggle\" hidden=\"\" type=\"button\">\u6682\u505c<\/button><\/figure><figure class=\"zg-figure\"><a class=\"zg-figure-link\" href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u56fe\u793a.png\" rel=\"noopener noreferrer\" target=\"_blank\"><img alt=\"\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u7814\u7a76\u56fe\u793a\" decoding=\"async\" height=\"1182\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u56fe\u793a-scaled.png\" width=\"5382\"\/><\/a><figcaption><a href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u805a\u5408\u7269\u51dd\u805a\u6001\u7eb3\u7c73\u529b\u5b66\u56fe\u793a.png\" rel=\"noopener noreferrer\" target=\"_blank\">\u67e5\u770b\u5927\u56fe \u2197<\/a><\/figcaption><\/figure><\/div><\/div>\n<div class=\"zg-references\"><h3>\u4ee3\u8868\u8bba\u6587<\/h3><ol><li>Song, Y.; Deng, Y.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1016\/j.polymer.2026.130638\" rel=\"noopener\" target=\"_blank\">Quantitative characterization of chain folding in crystalline polymers<\/a>. <em>Polymer<\/em> <strong>2026<\/strong>, <em>364<\/em>, 130638.<\/li><li>Zhang, X.; Zhang, H.; Lu, S.; Song, Y.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1021\/acs.macromol.5c01007\" rel=\"noopener\" target=\"_blank\">Direct Detection of the Chain Trajectory and Long-Range Correlation in Crystalline-Amorphous Polymer Networks by Single-Molecule Force Spectroscopy<\/a>. <em>Macromolecules<\/em> <strong>2025<\/strong>, <em>58<\/em> (12), 6170\u20136177.<\/li><li>Ma, Z.; Yang, P.; Zhang, X.; Jiang, K.; Song, Y.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1021\/acsmacrolett.9b00607\" rel=\"noopener\" target=\"_blank\">Quantifying the Chain Folding in Polymer Single Crystals by Single-Molecule Force Spectroscopy<\/a>. <em>ACS Macro Lett.<\/em> <strong>2019<\/strong>, <em>8<\/em> (9), 1194\u20131199.<\/li><li>Liu, K.; Song, Y.; Feng, W.; Liu, N.; Zhang, W.; Zhang, X. <a href=\"https:\/\/doi.org\/10.1021\/ja108022h\" rel=\"noopener\" target=\"_blank\">Extracting a Single Polyethylene Oxide Chain from a Single Crystal by a Combination of Atomic Force Microscopy Imaging and Single-Molecule Force Spectroscopy: Toward the Investigation of Molecular Interactions in Their Condensed States<\/a>. <em>J. Am. Chem. Soc.<\/em> <strong>2011<\/strong>, <em>133<\/em> (10), 3226\u20133229.<\/li><\/ol><\/div><\/section>\n\n<section aria-labelledby=\"single-molecule-techniques-title\" class=\"zg-section\" id=\"single-molecule-techniques\" style=\"--zg-accent:#8dbde0\"><div class=\"zg-heading\"><span aria-hidden=\"true\" class=\"zg-number\">04<\/span><h2 id=\"single-molecule-techniques-title\">\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1<\/h2><\/div>\n<div class=\"zg-topic-grid\"><div class=\"zg-copy\"><p class=\"zg-intro\"><strong>\u7814\u7a76\u95ee\u9898\uff1a<\/strong>\u539f\u5b50\u529b\u663e\u5fae\u955c\u529b\u8c31\u4e3b\u8981\u63d0\u4f9b\u529b\u4e0e\u8ddd\u79bb\u4fe1\u606f\uff0c\u5982\u4f55\u8fdb\u4e00\u6b65\u83b7\u5f97\u53d7\u529b\u8fc7\u7a0b\u4e2d\u5206\u5b50\u7ed3\u6784\u3001\u5316\u5b66\u53d8\u5316\u4e0e\u9897\u7c92\u4f4d\u7f6e\u7684\u4fe1\u606f\uff1f\u6211\u4eec\u5173\u6ce8\u591a\u79cd\u6d4b\u91cf\u4fe1\u53f7\u5728\u5355\u5206\u5b50\u3001\u5355\u9897\u7c92\u5c3a\u5ea6\u4e0a\u7684\u5173\u8054\u4e0e\u540c\u6b65\u3002<\/p><p class=\"zg-intro\"><strong>\u5177\u4f53\u5de5\u4f5c\uff1a<\/strong>\u5c06\u539f\u5b50\u529b\u663e\u5fae\u955c\u4e0e\u7ea2\u5916\u5149\u8c31\u76f8\u7ed3\u5408\uff0c\u642d\u5efa\u5149\u8c03\u5236\u529b\u8026\u5408\u76f8\u5173\u8c31\u63a2\u6d4b\u7cfb\u7edf\uff0c\u5e76\u7ed3\u5408\u7a7a\u6c14\u76f8\u5355\u5206\u5b50\u529b\u8c31\uff0c\u540c\u6b65\u68c0\u6d4b\u4e0e\u6307\u8ba4\u805a\u5408\u7269\u5355\u5206\u5b50\u529b\u5316\u5b66\u8fc7\u7a0b\u4e2d\u7684\u529b\u5b66\u548c\u5316\u5b66\u4fe1\u53f7\u3002\u53d1\u5c55AFM\u2013TIRF\u8054\u7528\u7cfb\u7edf\uff0c\u5f00\u5c55\u5355\u9897\u7c92\u8367\u5149\u6210\u50cf\u4e0e\u5149\u8c31\u6d4b\u91cf\uff1b\u5229\u7528\u7eb3\u7c73\u5c3a\u5ea6\u5316\u5b66\u6210\u50cf\u7814\u7a76\u805a\u5408\u7269\u6750\u6599\u7684\u7eb3\u7c73\u5206\u76f8\u884c\u4e3a\u3002<\/p><\/div><div class=\"zg-topic-media\"><figure class=\"zg-motion\"><div class=\"zg-motion-canvas\"><img alt=\"\u5355\u5206\u5b50\u529b\u8c31\u4e0e\u7ea2\u5916\u8054\u7528\u52a8\u6001\u793a\u610f\" data-animation=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1\u52a8\u753b.webp\" data-still=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1\u5c01\u9762.jpg\" decoding=\"async\" height=\"540\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1\u5c01\u9762.jpg\" width=\"960\"\/><\/div><button aria-label=\"\u6682\u505c\u5355\u5206\u5b50\u529b\u8c31\u4e0e\u7ea2\u5916\u8054\u7528\u52a8\u6001\u793a\u610f\" aria-pressed=\"false\" class=\"zg-motion-toggle\" hidden=\"\" type=\"button\">\u6682\u505c<\/button><\/figure><figure class=\"zg-figure\"><a class=\"zg-figure-link\" href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1\u56fe\u793a.png\" rel=\"noopener noreferrer\" target=\"_blank\"><img alt=\"\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1\u7814\u7a76\u56fe\u793a\" decoding=\"async\" height=\"988\" loading=\"lazy\" src=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1\u56fe\u793a.png\" width=\"2496\"\/><\/a><figcaption><a href=\"https:\/\/www.zhangwenkegroup.com\/wp-content\/uploads\/2026\/09\/\u7814\u7a76\u65b9\u5411\uff5c\u65b0\u578b\u5355\u5206\u5b50\u6280\u672f\u7684\u5f00\u53d1\u56fe\u793a.png\" rel=\"noopener noreferrer\" target=\"_blank\">\u67e5\u770b\u5927\u56fe \u2197<\/a><\/figcaption><\/figure><\/div><\/div>\n<div class=\"zg-references\"><h3>\u4ee3\u8868\u8bba\u6587\u4e0e\u4e13\u5229<\/h3><ol><li>Cao, X.; Wang, W.; Jiang, Y.; Feng, W.; Xu, S.; Xu, W.; Zhang, W. <a href=\"https:\/\/doi.org\/10.1063\/5.0210704\" rel=\"noopener\" target=\"_blank\">An atomic force microscopy and total internal reflection fluorescence microscopy correlated system (AFM\u2013TIRF) for fluorescence imaging and spectroscopy of a single particle<\/a>. <em>Rev. Sci. Instrum.<\/em> <strong>2024<\/strong>, <em>95<\/em> (7), 073706.<\/li><li>Zhang, W.; Ma, Z.; Jiang, Y.; Feng, W.; Song, Y. <a href=\"https:\/\/image-ppubs.uspto.gov\/dirsearch-public\/print\/downloadPdf\/12320826\" rel=\"noopener\" target=\"_blank\">Single-Molecule Force Spectroscopy-Infrared Spectroscopy (SMFS-IR) Coupling Method and System, and Device<\/a>. US Patent 12,320,826 B1, June 3, <strong>2025<\/strong>.<\/li><\/ol><\/div><\/section>\n<\/div>\n<script>\n(function(){\n  document.querySelectorAll('.zg-references').forEach(function(section){\n    var list=section.querySelector('ol');\n    if(!list||list.children.length<2||section.querySelector('details'))return;\n    var count=list.children.length-1;\n    var details=document.createElement('details');details.className='zg-reference-more';\n    var summary=document.createElement('summary');\n    var expand=document.createElement('span');expand.className='zg-ref-expand';\n    expand.textContent='\u5c55\u5f00\u66f4\u591a\uff08'+count+(section.closest('#single-molecule-techniques')?'\u9879':'\u7bc7')+'\uff09';\n    var collapse=document.createElement('span');collapse.className='zg-ref-collapse';collapse.textContent='\u6536\u8d77';\n    summary.appendChild(expand);summary.appendChild(collapse);details.appendChild(summary);\n    var remainder=document.createElement('ol');remainder.start=2;\n    while(list.children.length>1)remainder.appendChild(list.children[1]);\n    details.appendChild(remainder);section.appendChild(details);\n  });\n})();\n(function(){var root=document.querySelector('.zg-research');if(!root)return;var reduced=window.matchMedia('(prefers-reduced-motion: reduce)'),states=[];root.querySelectorAll('.zg-motion').forEach(function(panel){var img=panel.querySelector('img'),button=panel.querySelector('button');if(!img||!button)return;var state={visible:false,paused:reduced.matches,active:false};function update(){var active=state.visible&&!state.paused&&!document.hidden;if(active!==state.active||!img.dataset.ready){img.src=active?img.dataset.animation:img.dataset.still;state.active=active;img.dataset.ready='true';}button.textContent=state.paused?'\u64ad\u653e':'\u6682\u505c';button.setAttribute('aria-label',(state.paused?'\u64ad\u653e':'\u6682\u505c')+img.alt);button.setAttribute('aria-pressed',String(state.paused));}state.update=update;states.push(state);button.hidden=false;button.addEventListener('click',function(){state.paused=!state.paused;update();});if('IntersectionObserver'in window){var observer=new IntersectionObserver(function(entries){state.visible=entries[0].isIntersecting;update();},{threshold:0.05});observer.observe(panel);}else{state.visible=true;}update();});document.addEventListener('visibilitychange',function(){states.forEach(function(s){s.update();});});reduced.addEventListener('change',function(e){states.forEach(function(s){s.paused=e.matches;s.update();});});})();<\/script>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u4e8e\u539f\u5b50\u529b\u663e\u5fae\u955c\uff08AFM\uff09\u7684\u5355\u5206\u5b50\u4e0e\u5355\u7c92\u5b50\u64cd\u7eb5\u6280\u672f\uff0c\u4e3a\u8ba4\u8bc6\u8d85\u5206\u5b50\u7ed3\u6784\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\u63d0\u4f9b\u4e86\u6709\u529b\u5de5\u5177\u3002\u4f9d\u6258\u8fd9\u4e00\u6280\u672f\uff0c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"zhang-inner-standard","meta":{"footnotes":""},"class_list":["post-232","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/pages\/232","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/comments?post=232"}],"version-history":[{"count":32,"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/pages\/232\/revisions"}],"predecessor-version":[{"id":532,"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/pages\/232\/revisions\/532"}],"wp:attachment":[{"href":"https:\/\/www.zhangwenkegroup.com\/index.php\/wp-json\/wp\/v2\/media?parent=232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}